If you’re relying on typical CoQ10 or omega-3 fish oil to boost your heart, brain, energy and immune health, here’s some shocking news.Your body may have difficulty absorbing these nutrients—so you might not be getting the health benefits you expected. Now there’s something far better: An amazing formula oMega Heart that floods your body with four times more CoQ10 than conventional formulas and two times more omega-3s than fish oil—in one natural pill.
|Suggested Use:||Take two capsules once daily.|
|Serving Size: 2 Capsules|
|Servings Per Container: 30|
|Amount Per Serving||% Daily Value†|
|Calories From Fat||7|
|Vitamin A (naturally occurring)||418 IU||8%|
|Total Omega-3 Fatty Acids||190mg||*|
|EPA (eicosapentaenoic acid)||100mg||*|
|DHA (docasahexaenoic acid)||55mg||*|
|*Daily Value not established|
Other Ingredients: Gelatin, medium chain triglycerides, purified water, beeswax, natural orange flavor, rosemary leaf extract, sorbitan monoleate, ascorbyl palmitate, cayenne fruit extract, annatto seed extract, caramel and titanium dioxide.
* Daily Value not established.
† Percent Daily Values are based on a 2,000 calorie diet.
Keep container tightly closed in a cool, dry and dark place. Keep out of reach of children.
Do not exceed recommended daily intake, unless directed by a healthcare practitioner. Individuals taking any prescription medications or who are under medical supervision should consult a doctor before taking any supplements. If pregnant or breastfeeding please consult your healthcare practitioner before taking this supplement. Food supplements should not be used as substitute for a varied balanced diet. Keep out of reach of children.
*All information is for reference purposes only. Statements regarding dietary supplements are not intended to diagnose, treat, cure or prevent any disease or health condition.
New Supplement Combines Powerful Heart-Healthy Duo
by VRP Staff
Two of the most powerful supplements involved in heart health are CoQ10-H2™ and krill oil. Each of these supplements also support the health in other ways. Beyond cardiovascular health, krill oil supports joint health and healthy inflammatory responses and, as a source of omega-3 fatty acids, is important in both cognitive function and mood. CoQ10 enhances kidney function, may offer benefits to people experiencing headaches, and is a powerful antioxidant involved in many aspects of well being. Now, to make it convenient to obtain optimal amounts of these two nutrients, we’ve combined CoQ10-H2 and krill oil into one supplement.
Krill oil has emerged as an effective way to obtain omega-3 fatty acids. Krill are small, red crustaceans that live in the cold waters off the Antarctic Ocean. They have a high content of EPA and DHA omega-3 fatty acids attached to their cell membranes via phospholipids. When omega-3s are bound to phospholipids, they are more easily absorbed and delivery to the brain is enhanced.1-3 Krill oil also contains astaxanthin, an antioxidant carotenoid that inhibits the oxidation of the omega-3 fatty acids found in krill oil, as well as flavonoids, vitamin A and alpha linolenic acid.
CoQ10-H2 is the reduced form of CoQ10 known as ubiquinol. In addition to its crucial function in ATP synthesis in mitochondria, the reduced form of Coenzyme Q10, as CoQ10-H2, is a fat-soluble antioxidant that traps and inactivates free radicals, particularly the highly reactive hydroxyl radical (OH) and the superoxide radical (O2-) in the lipid membranes of cells and their mitochondria.
CoQ10-H2 is significantly more bioavailable than the oxidized form of CoQ10 (ubiquinone). In addition, CoQ10-H2, produces sustained, elevated blood levels of total Coenzyme Q10, at lower dosages.
A recently published single-blind, placebo controlled, four-week study of healthy Japanese subjects has shown that CoQ10-H2 was absorbed rapidly and efficiently from the gastrointestinal tract after oral administration. The Japanese researchers reported that the benefits of CoQ10-H2 were attributable to the more than 210 percent increase in blood levels of ubiquinol. Importantly, this study also revealed the safety of CoQ10-H2 at dosages up to 300mg. per day.4
Krill Oil: An Emerging Superstar
Krill oil has been shown in numerous studies to play an important role in various aspects of optimal health.
Krill is perhaps best known for its ability to support heart health by virtue of its involvement in balanced cholesterol metabolism. One group of researchers measured levels of triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol in rats fed a high-fat diet. The levels were measured before and after the rats were given krill oil. After four weeks’ consumption of krill oil, there was a balancing effect on triglycerides, total cholesterol and LDL cholesterol. There was no effect on HDL cholesterol at the lower doses of krill, but higher doses of krill resulted in a balancing effect on HDL cholesterol.5
Other studies have achieved similar results. In one study, researchers observed that relatively low doses of krill oil administered to overweight rats for 4 weeks considerably improved both fat deposition and susceptibility to imbalanced inflammatory processes. Rats fed krill oil also had more balanced triglyceride levels in both the liver and heart. The study authors also noted balanced levels of LDL cholesterol in rats given either krill oil or fish oil.6
The researchers believe the beneficial effects of the krill oil were due to a lower concentration of the endocannabinoids in the visceral adipose tissue and of anandamide in the liver and heart, which, in turn, was associated with lower levels of arachidonic acid in membrane phospholipids. Visceral adipose tissue accumulation and the metabolic effects that occur after its deposition, might be due in part to dysregulation of the endocannabinoid system. Arachidonic acid is involved in inflammatory processes and krill oil’s ability to lower arachidonic acid levels results in positive effects in this area.6
A human study involving 129 subjects also investigated the effects of krill oil and fish oil on DHA and EPA levels in the body as well as balanced cholesterol metabolism. The study found that plasma concentrations of the omega-3 fatty acids EPA, DPA (docosapentaenoic acid) and DHA increased significantly in both the krill oil and fish oil groups compared with the control group following daily supplementation for 7 weeks. Since the subjects in the krill oil group received 62.8 percent of the total amount of omega-3 fatty acids received by the subjects in the fish oil group, these findings indicate that the bioavailability of the omega-3 fatty acids from krill oil is as efficient—or possibly more efficient—as omega-3 fatty acids from fish oil.7
In the group given krill oil, there also was a significant increase in the HDL-cholesterol/triglyceride ratio. This effect wasn’t seen with the fish oil group.7 The ratio between triglycerides and HDL-cholesterol has been shown to be an important factor in optimal heart health.8-9
Although none of the interventions significantly changed triglyceride levels, krill oil was able to maintain balanced triglyceride levels in those subjects having the highest baseline values.7
Zhu et al. also investigated Krill’s role in colon health. They administered krill to a human colon cell line and determined krill oil promoted a healthy cell cycle.5
Human studies also have found remarkable effects of krill oil supplementation on healthy younger women experiencing monthly mild mood-related challenges.10 Krill oil also has been found to support healthy inflammatory processes in subjects concerned about bone and joint support.11
CoQ10-H2: Antioxidant Extraordinaire
Certain people—especially those who have good reason to be concerned with heart health—have a difficult time achieving adequate plasma levels of CoQ10 even when they’re supplemented with 900 mg per day. These people often have plasma total CoQ10 levels of less than 2.5 µg/ml—possibly due to imbalanced inflammatory processes in the intestine—and don’t experience optimal benefits from supplementation.
To determine if CoQ10-H2 would solve this problem, researchers first gave 7 subjects with low CoQ10 levels and suboptimal heart health varying dosages of CoQ10. When the CoQ10 failed to substantially raise CoQ10 levels, the researchers switched the subjects to varying dosages of CoQ10-H2, from 150 mg to 900 mg per day. The researchers observed a dramatic increase in plasma CoQ10 levels in all seven patients when switched from supplemental CoQ10 to CoQ10-H2. Mean plasma CoQ10 levels increased from 1.6 µg/ml up to 6.5 µg/ml. The subjects also experienced positive effects in heart health after supplementation with CoQ10-H2.12
Scientists also have studied CoQ10-H2 for its role in balancing healthy cholesterol levels. Researchers gave 53 healthy males 150 mg per day of CoQ10-H2 for two weeks. Mean CoQ10 plasma levels increased 4.8-fold after supplementation. Furthermore, the subjects experienced balanced plasma levels of LDL cholesterol after CoQ10-H2 supplementation. This effect was especially pronounced in small dense LDL particles, which are known to have a particularly strong effect on heart health.13
CoQ10-H2 also has been shown to play a role in kidney health and modulates inflammatory processes in vitro by decreasing the activity of lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and chemokines.14-15
Krill oil and CoQ10-H2 both play important roles in cardiovascular health. Their beneficial effects also extend to other aspects of health. Now it’s easier than ever to achieve the benefits these two natural substances have to offer by consuming both in one supplement.
1. Wijendran V, Huang MC, Diau GY, et al. Efficacy of dietary arachidonic acid provided as triglyceride or phospholipids as substrates for brain arachidonic acid accretion in baboon neonates. Pediatr Res. 2002;51:265-272.
2. Goustard-Langelier B, Guesnet P, Durand G, et. al. n-3 and n-6 fatty acid enrichment by dietary fish oil and phospholipids sources in brain cortical areas and nonneural tissues of formula-fed piglets. Lipids. 1999;34:5-16.
3. No authors listed. Krill Oil Monograph. Alternative Medicine Review. 2010;15(1):84-86.
4. Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on Safety and Bioavailability of Ubiquinol (QH™) After Single and 4-week Multiple Oral Administration to Healthy Volunteers. Regulatory Toxicology Pharmacology. 2007 February; 47(1):19-28.
5. Jia-Jin Zhu, Jia-Hui Shi, Wen-Bin Qian, Zhen-Zhen Cai, and Duo Li. Effects of Krill Oil on serum lipids of hyperlipidemic rats and human SW480 cells. Lipids in Health and Disease. 2008, 7:30
6. Barbara Batetta, Mikko Griinari, Gianfranca Carta, Elisabetta Murru, Alessia Ligresti, Lina Cordeddu, Elena Giordano, Francesca Sanna, Tiziana Bisogno, Sabrina Uda, Maria Collu, Inge Bruheim, Vincenzo Di Marzo10 and Sebastiano Banni. Endocannabinoids May Mediate the Ability of (n-3) Fatty Acids to Reduce Ectopic Fat and Inflammatory Mediators in Obese Zucker Rats. J. Nutr. 139:1495-1501, 2009.
7. Stine M. Ulven, Bente Kirkhus, Amandine Lamglait, Samar Basu, Elisabeth Elind, Trond Haider, Kjetil Berge, Hogne Vik, and Jan I. Pedersen. Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers. Lipids. 2011 January;46(1):37-46.
8. da Luz PL, Favarato D, Faria-Neto JR, Jr, Lemos P, Chagas AC. High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease. Clinics (Sao Paulo) 2008;63:427-432.
9. Bittner V, Johnson BD, Zineh I, Rogers WJ, Vido D, Marroquin OC, Bairey-Merz CN, Sopko G. The triglyceride/high-density lipoprotein cholesterol ratio predicts all-cause mortality in women with suspected myocardial ischemia: a report from the Women’s Ischemia Syndrome Evaluation (WISE). Am Heart J. 2009;157:548-555.
10. Sampalis F, Bunea R, Pelland MF, Kowalski O, Duguet N, Dupuis S. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev. 2003;8:171-9.
11. Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr. 2007;26:39-48.
12. Peter H. Langsjoen and Alena M. Langsjoen. Supplemental ubiquinol in patients with advanced congestive heart failure. BioFactors. 2008;32:119-128
13. Constance Schmelzer, Petra Niklowitz, Jurgen G. Okun, Dorothea Haas, Thomas Menke and Frank Doring. Ubiquinol-Induced Gene Expression Signatures are Translated into Altered Parameters of Erythropoiesis and Reduced Low Density Lipoprotein Cholesterol Levels in Humans. IUBMB Life. January 2011;63(1):42-48.
14. Akira Ishikawa, Hiroo Kawarazaki, Katsuyuki Ando, Megumi Fujita, Toshiro Fujita, Yukio Homma. Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. Clin Exp Nephrol. 2011;15:30-33.
15. Constance Schmelzer, Gerti Lorenz, Gerald Rimbach, and Frank Döring. In vitro effects of the reduced Form of Coenzyme Q10 on Secretion Levels of TNF-a and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1. J Clin Biochem Nutr. January 2009;44:62-66.