CortiTrophin®

This product is a blend of vitamins, amino acids, botanicals and adrenal concentrate designed to nourish the adrenal glands and support healthy blood sugar metabolism. This formula features adaptogenic herbs that support the hypothalamus-pituitary-adrenal (“HPA”) axis, the portion of the neuroendocrine system that governs the stress response. These well-researched botanicals, especially Bacopa, also help promote cognitive function and memory, which may be negatively impacted with prolonged stress.*

Suggested Use: Take 2 capsules with the morning meal. Additionally, 1 or 2 capsules may be taken at midday or as directed by your healthcare provider. Caution: If you have a medical condition, especially high blood pressure, or if you are taking blood thinners or other medication, or if you are pregnant or nursing, do not use this product without consulting a healthcare professional.

Ingredients:  
Serving Size: 2 capsules Servings Per Container: 45
Amount Per Serving % Daily Value
Vitamin C (as calcium ascorbate) 100mg 167%
Thiamin (as thiamin hydrochloride and thiamin pyrophosphate) 75mg 5,000%
Vitamin B6 (as pyridoxal-5-phosphate) 20mg 1,000%
Pantothenic Acid (as calcium pantothenate) 300mg 3,000%
Calcium (from calcium abcorbate and calcium pantothenate) 36mg 4%
N-Acetyl Tyrosine 175mg *
Adrenal Glandular 100mg *
Citrus Bioflavanoids 100mg *
L-Carnitine L-Tartrate 100mg *
Eleuthero root extract 90mg *
Licorice root extract 90mg *
Rhodiola root extract 90mg *
Bacopa whole herb extract 80mg *
*Daily Value not established
Other Ingredients: Hydroxypropylmethylcellulose (vegetarian capsule) and L-leucine.

Keep container tightly closed in a cool, dry and dark place. Keep out of reach of children.

Caution:
If you have a medical condition, especially high blood pressure, or if you are taking blood thinners or other medication, or if you are pregnant or nursing, do not use this product without consulting a healthcare professional.
Do not exceed recommended daily intake, unless directed by a healthcare practitioner. Food supplements should not be used as substitute for a varied balanced diet. Keep out of reach of children.

*All information is for reference purposes only. Statements regarding dietary supplements are not intended to diagnose, treat, cure or prevent any disease or health condition.

All-Natural Support for Daily Stress Relief
by VRP Staff

Whether it’s the current political climate or the unrelenting threat of lost jobs and homes, there’s no shortage of stressors to keep you up at night. Unfortunately, it’s not just your morale that takes a beating when your nerves wear down.

The truth is, stress is much more than just a mental phenomenon. It can have a devastating effect on your body, too. Research has linked high stress levels to a number of effects—on organs such as the heart, impacts on blood sugar regulation and weight maintenance and inefficient digestive function and altered immune function.1-17

Needless to say, a stress-free life is impossible to achieve—but while you can’t eliminate stress from your life altogether, you can boost your body’s resistance to stress and resilience in the face of daily challenges.

One way to do that is with “adaptogens”—strengthening botanicals that can improve your body’s response to stress and promote its recovery after stressful events.18 Eleutherococcus senticosus, Ashwagandha (Withania somnifera) and Schisandra chinensis—all of which you’ll find in VRP’s formula AdaptaPhase® 1—are among those adaptogenic herbs that have been shown to boost endurance and enhance mental performance in fatigued patients, most likely by modulating the secretion of stress hormones in the hypothalamus-pituitary-adrenal (HPA) axis.19

Addressing adrenal insufficiency—a state in which levels of the stress hormone cortisol are depleted—is another key element of effective stress management. And, as it turns out, several natural compounds can assist herbal adaptogens in supporting adrenal health. Licorice root extract, for example, contains components (including glycyrrhizin and glycyrrhetinic acid) that can boost net cortisol availability and replenish the adrenal glands.20-21

Bacopa monnieri also has adaptogenic benefits, with studies revealing this herb’s positive impact on energy levels, mental acuity and mood.22-25 Meanwhile, the amino acid tyrosine increases the synthesis of the key neurotransmitters dopamine and catecholamine and minimizes stress-related declines in both performance and noradrenaline levels.26

VRP’s formula CortiTrophin® combines all of these nutrients and botanicals—along with citrus bioflavonoids, L-carnitine, powdered adrenal gland, Eleutherococcus senticosus, Rhodiola rosea root, vitamin C and an array of essential B vitamins—in a single, synergistic daily supplement designed to nourish your adrenal glands, balance cortisol levels and buffer your body against the effects of stress.

Last, but not least, supplementing with nutrients that promote a natural sense of calm can make all the difference in your fight against daily stress. L-theanine, for example, relaxes your mind without leaving you drowsy; this unique amino acid from green tea increases your brain’s alpha wave activity.27 Similarly, human studies have shown that GABA can minimize anxiety plus enhance relaxation and support immune health under stressful conditions.28 Passion flower fights tension, restlessness, irritability and minimizes trouble sleeping—while valerian helps to regulate the nervous system, delivering safe, natural and proven calming effects.29-32

You can find all of these stress-busting ingredients combined in the daily calming formula Allay™, available now from Vitamin Research Products®.

References:
1. Randolfi EA. Developing A Stress Management And Relaxation Center For The Worksite. Worksite Health. 1997 Summer; Vol.4, No. 3, 40-44.
2. Black PH. The inflammatory consequences of psychologic stress: relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II. Med Hypotheses. 2006;67(4):879-91.
3. Vogelzangs N, Beekman AT, Milaneschi Y, et al. Urinary cortisol and six-year risk of all-cause and cardiovascular mortality. J Clin Endocrinol Metab. 2010 Nov;95(11):4959-64.
4. Spruill TM. Chronic psychosocial stress and hypertension. Curr Hypertens Rep. 2010 Feb;12(1):10-6.
5. Evolahti A, Hultcrantz M, Collins A. Psychosocial work environment and lifestyle as related to lipid profiles in perimenopausal women. Climacteric. 2009 Apr;12(2):131-45.
6. Black PH, Garbutt LD. Stress, inflammation and cardiovascular disease. J Psychosom Res. 2002 Jan;52(1):1-23.
7. Hamer M, O’Donnell K, Lahiri A, et al. Salivary cortisol responses to mental stress are associated with coronary artery calcification in healthy men and women. Eur Heart J. 2010 Feb;31(4):424-9.
8. Block JP, He Y, Zaslavsky AM, et al. Psychosocial stress and change in weight among US adults. Am J Epidemiol. 2009 Jul 15;170(2):181-92.
9. Hamer M, Stamatakis E. Inflammation as an intermediate pathway in the association between psychosocial stress and obesity. Physiol Behav. 2008 Jul 5;94(4):536-9.
10. Heraclides A, Chandola T, Witte DR, et al. Psychosocial stress at work doubles the risk of type 2 diabetes in middle-aged women: evidence from the Whitehall II study. Diabetes Care. 2009 Dec;32(12):2230-5.
11. Kim-Dorner SJ, Simpson-McKenzie CO, Poth M, et al. Psychological and physiological correlates of insulin resistance at fasting and in response to a meal in African Americans and Whites. Ethn Dis. 2009 Spring;19(2):104-10.
12. Jansson C, Wallander MA, Johansson S, et al. Stressful psychosocial factors and symptoms of gastroesophageal reflux disease: a population-based study in Norway. Scand J Gastroenterol. 2010;45(1):21-9.
13. Patacchioli FR, Angelucci L, Dellerba G, et al. Actual stress, psychopathology and salivary cortisol levels in the irritable bowel syndrome (IBS). J Endocrinol Invest. 2001 Mar;24(3):173-7.
14. Heitkemper M, Jarrett M, Cain K, et al. Increased urine catecholamines and cortisol in women with irritable bowel syndrome. Am J Gastroenterol. 1996 May;91(5):906-13.
15. Quan C, Talley NJ. Management of peptic ulcer disease not related to Helicobacter pylori or NSAIDs. Am J Gastroenterol. 2002 Dec;97(12):2950-61.
16. Lazebnik LB, Arbuzova VG, Sokolova GN, et al. Role of stress in the etiopathogenesis of duodenal ulcer in young patients. Eksp Klin Gastroenterol. 2002;(5):30-3, 126-7.
17. Bauer ME, Jeckel CM, Luz C. The role of stress factors during aging of the immune system. Ann N Y Acad Sci. 2009 Feb;1153:139-52.
18. Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern Med Rev. 1999 Aug;4(4):249-65.
19. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219.
20 Tamura Y, Nishikawa T, Yamada K, et al. Effects of glycyrrhetinic acid and its derivatives on delta 4-5 alpha- and beta-reductase in rat liver. Arneimittelforschung. 1979;29(4):647-9.
21. van Uum SH, Walker BR, Hermus AR, et al. Effect of glycyrrhetinic acid on 11 beta-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects. Clin Sci (Colch) 2002;102:203-11.
22. Roodenrys S, Booth D, Bulzomi S, et al. The chronic effects of Brahmi (Bacopa monniera) on human memory. Neuropsychopharmacology. 2002 Aug27;(2):279-81.
23. Sairam K, Dorababu M, et al. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine. 2002 Apr;9(3):207-11.
24. Calabrese C, et al. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14(6):707-13.
25. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001 Aug;156(4):481-4.
26. Deijen JB, Wientjes CJ, Vullinghs HF, et al. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999 Jan 15;48(2):203-9.
27. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8.
28. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.
29. Krenn L. Passion Flower (Passiflora incarnata L.)—a reliable herbal sedative. [Article in German]. Wien Med Wochenschr. 2002;152(15-16):404-6.
30. No authors listed. Valeriana officinalis, Monograph. Altern Med Rev. 2004 Dec;9(4):438-41.
31. Benke D, Barberis A, Kopp S, et al. GABA(A) receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2008 Jun 17. Published Online Ahead of Print.
32. Murphy K, Kubin ZJ, Shepherd JN, Ettinger RH. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine. 2010 Jul;17(8-9):674-8.

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